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This is an initial public offering of shares of common stock by Verve Therapeutics, Inc. We are offering 14,035,789 shares of our common stock. The initial public offering price is $19.00 per share.Prior to this offering, there has been no public market for our common stock. Our common stock has been approved for listing on the Nasdaq Global Select Marketunder the symbol “VERV.”We are an “emerging growth company” as that term is used in the Jumpstart Our Business Startups Act of 2012and, as such, have elected to comply with certain reduced public company reporting requirements for this prospectus and future filings. See “Prospectus summary—Implications of being an emerging growth company and a smaller reportingcompany.”We have granted the underwriters an option for a period of 30 days to purchase up to 2,105,368 additional shares of common stock from us at the public offeringprice, less underwriting discounts and commissions.