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SyntheX has developed proprietary platforms that leverage the power of synthetic biology to build next generation drug discovery engines. Using genetic engineering, SyntheX's platform technologies rely on functional intracellular drug selection as opposed to in vitro screening, which allows the company to discover functional molecular glues using a pre-specified E3 ligase and a neosubstrate of interest

SyntheX and Bristol Myers Squibb Enter Into a Research Collaboration to Discover and Develop Targeted Protein Degradation (TPD) Therapeutics

SyntheX, Inc., an emerging growth biotechnology company innovating next-generation functional drug discovery engines, today announced a research collaboration and license agreement with Bristol Myers Squibb to discover, develop and commercialize novel small molecules using SyntheX's ToRNeDO platform for protein degradation

By AP News
Published - Oct 04, 2022, 08:38 AM ET
Last Updated - Jul 15, 2024, 06:30 AM EDT

-Collaboration will leverage SyntheX's proprietary ToRNeDO molecular glue discovery platform to discover small molecule degraders against targets of interest-

-SyntheX will receive a combined upfront of cash and an investment and will be eligible for potential performance-based milestone payments totaling up to $550 million, as well as royalties on net sales-

SAN FRANCISCO, Oct. 4, 2022 /PRNewswire/ -- SyntheX, Inc., an emerging growth biotechnology company innovating next-generation functional drug discovery engines, today announced a research collaboration and license agreement with Bristol Myers Squibb to discover, develop and commercialize novel small molecules using SyntheX's ToRNeDO platform for protein degradation.

The collaboration will focus on discovering molecular glue degraders. Under the terms of the agreement, SyntheX will receive a combined upfront of cash and an investment and is eligible for up to $550 million in performance-based milestone payments, as well as royalties on global net sales of products.

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