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DUBLIN--(BUSINESS WIRE)--Dec 2, 2022--
The "Atopic Dermatitis Treatment Market Forecast - Epidemiology & Pipeline Analysis 2022-2027" report has been added to ResearchAndMarkets.com's offering.
Atopic dermatitis (AD) is a chronic, pruritic inflammatory skin condition that typically affects the face (cheeks), neck, arms, and legs but usually spares the groin and axillary regions. Atopic dermatitis (AD), also known as atopic eczema, is a chronic relapsing inflammatory skin condition. Atopic dermatitis (AD) is common worldwide. People of all ages, from newborns to adults 65 years and older, live with this condition. AD is associated with an increased risk of multiple comorbidities, including food allergy, asthma, allergic rhinitis, and mental health disorders. Due to such factors, the atopic dermatitis treatment market is growing immensely during the forecast period.
Atopic Dermatitis Treatment
Most atopic dermatitis patients are treated with topical therapies, particularly low to mid-potency topical steroids and TCIs. These two classes of drugs constituted nearly all AD prescriptions. Despite their widespread use, existing topical therapies all possess substantial shortcomings:
1. Topical corticosteroids, in combination with Vitamin D creams and antihistamines, are the first line of treatment for AD. The topical steroids aim to provide short-term itch relief to break the itch-scratch reflex cycle - the primary cause of reinfection. Although in more mild cases, these therapies may be effective, in moderate/severe cases, long-term use (of steroids) tends to do more harm than benefit. Prolonged use damages and dries out the epidermal layer of skin, which, somewhat paradoxically, ends up actually worsening the itch-scratch complex.
2. Topical steroids pose a particular concern in pediatric patients due to the risk of systemic absorption, the consequent risk of HPA axis suppression, and potential developmental problems. Chronic use of topical steroids in AD patients is generally avoided.
3. Second-line agents include immunosuppressant medications such as topical calcineurin inhibitors, including Pimecrolimus (Elidel) and Tacrolimus (Protopic). Topical calcineurin inhibitors are generally seen as providing less symptomatic improvement than topical steroids and are also associated with some application site burning. In 2005 the FDA placed a boxed warning on the labels of both TCIs regarding a potential increased risk of cancers, especially lymphomas.
ATOPIC DERMITIS: CLINICAL TRIALS SCENARIO
The clinical trial portfolio contains 153+ trials in various development phases. Most industry-sponsored drugs in active clinical development for AD are in the Phase II stage. The distribution of clinical trials across Phase I-IV indicates that the vast majority of trials for atopic dermatitis have been in the mid-phase of development, with 47% of trials in Phase I/II & II and only 29% in Phase II/III-III.
MARKET DRIVERS & TRENDS
Increasing Adoption of Biological Therapies
Anticipated Launch of Emerging Drugs
Focus on Novel Drugs with Novel Mechanism
SEGMENTATION
Segmentation by Drug Class
Segmentation by Gender Type
Segmentation by Age Group
Segmentation by Severity Type
Key Vendors
Other Prominent Vendors
For more information about this report visit https://www.researchandmarkets.com/r/193rmc
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KEYWORD:
INDUSTRY KEYWORD: HEALTH GENERAL HEALTH RESEARCH PHARMACEUTICAL SCIENCE BIOTECHNOLOGY
SOURCE: Research and Markets
Copyright Business Wire 2022.
PUB: 12/02/2022 12:43 PM/DISC: 12/02/2022 12:43 PM
http://www.businesswire.com/news/home/20221202005433/en